Cell Calcium. 2003 May-Jun;33(5-6):509-18.
The TRPV6 gene, cDNA and protein.
Hirnet, D., Olausson, J., Fecher-Trost, C., Bodding, M., Nastainczyk, W., Wissenbach, U., Flockerzi, V., Freichel, M.,
["Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat des Saarlandes, D 66421 Homburg, Germany."]
["Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat des Saarlandes, D 66421 Homburg, Germany."]
The mouse TRPV6 gene is localized on chromosome 6 and extends over 15.66kb. The encoded protein comprises 727 amino acid residues with a calculated relative molecular mass of 83,210Da. TRPV6 is glycosylated and both variants, the glycosylated and the de-glycosylated proteins, are recognized by various polyclonal and monoclonal antibodies, which were raised against TRPV6. Like human TRPV6, mouse TRPV6 binds calmodulin in the presence, but not in the absence of Ca2+. TRPV6 is abundantly expressed in mouse pancreas and placenta, and to a much lesser extend in mouse stomach and kidney. No transcript expression was detected in poly(A)+RNA isolated from heart, brain, intestine, esophagus or aortic endothelial cells.
PMID: 12765696
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Characterization
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| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
| TRP channel | Interactor | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPV6 |
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Calmodulin | Fluorescence probe labeling | 1:1 | 43 nM | 12765696 | ||||
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)