ZBTB17 / TRP channels

Name: Zinc finger and BTB domain-containing protein 17 (ZBTB17)
Official Symbol: ZBTB17 provided by HGNC
Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
7709External Q13105External DIP-5968NExternal Q13105External MINT-1527698External 113503External Q13105External   hsa:7709External 604084External
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
22642External Q60821External DIP-48690NExternal   UNK-5943384External 204631External Q60821External   mmu:22642External  
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
313666External Q5XIU3External     UNK-5933514External 260507External Q5XIU3External   rno:313666External  
PPI pairs:
Biological Process:
  • GO:0006987 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : activation of signaling protein activity involved in unfolded protein response
  • GO:0007398 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : ectoderm development
  • GO:0001702 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : gastrulation with mouth forming second
  • GO:0045786 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of cell cycle
  • GO:0045893 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of transcription, DNA-dependent
  • GO:0006351 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : transcription, DNA-dependent
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ZBTB17 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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