Troponin I 3 / TRP channels
Name: Troponin I, cardiac muscle
(Troponin I 3)
Official Symbol: TNNI3
provided by HGNC
Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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7137![]() |
P19429![]() |
DIP-34065N![]() |
P19429![]() |
MINT-2801556![]() |
112991![]() |
P19429![]() |
hsa:7137![]() |
191044![]() |
|
Mouse
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21954![]() |
P48787![]() |
DIP-31388N![]() |
P48787![]() |
MINT-4138144![]() |
204266![]() |
P48787![]() |
mmu:21954![]() |
||
Rat
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29248![]() |
P23693![]() |
P23693![]() |
UNK-5374239![]() |
247923![]() |
P23693![]() |
rno:29248![]() |
Biological Process:
- GO:0060048
: cardiac muscle contraction
- GO:0006874
: cellular calcium ion homeostasis
- GO:0030049
: muscle filament sliding
- GO:0032780
: negative regulation of ATPase activity
- GO:0006940
: regulation of smooth muscle contraction
- GO:0001980
: regulation of systemic arterial blood pressure by ischemic conditions
- GO:0001570
: vasculogenesis
- GO:0055010
: ventricular cardiac muscle tissue morphogenesis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:191044
: Cardiomyopathy, familial hypertrophic, 7 (OMIM:613690
)
- OMIM:191044
: Cardiomyopathy, familial restrictive (OMIM:115210
)
- OMIM:191044
: Cardiomyopathy, dilated, 2A (OMIM:611880
)
- OMIM:191044
: Cardiomyopathy, dilated, 1FF (OMIM:613286
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
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Troponin I 3 | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library | 12525172 | |
TRPP2 |
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Troponin I 3 | Inference | Prediction | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPP1 |
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Troponin I 3 | Fusion protein-pull down assay | Human | 682-968 | E. coli | Human | Full-length | E. coli | 12525172 |
TRPP2 |
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Troponin I 3 | Fusion protein-pull down assay | Human | 562-805 | E. coli | Human | Not specified | Not specified | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
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Troponin I 3 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12525172 | |
TRPP1 |
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Troponin I 3 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12525172 | |
TRPP1 |
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Troponin I 3 | Co-immunoprecipitation | Human heart tissue | 12525172 | |||||
TRPP2 |
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Troponin I 3 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12809519 | |
TRPP2 |
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Troponin I 3 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12809519 | |
TRPP2 |
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Troponin I 3 | Co-immunoprecipitation | Human adult cardiac tissue | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
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Troponin I 3 | Yeast two-hybrid | Human | 872-927 | Human | 1-107 | 12525172 | ||
TRPP1 |
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Troponin I 3 | Yeast two-hybrid | Human | 872-927 | Human | 106-158 | 12525172 | ||
TRPP2 |
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Troponin I 3 | Yeast two-hybrid | Human | 630-705 | Human | Not determined | 12809519 | ||
TRPP2 |
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Troponin I 3 | Yeast two-hybrid | Human | 562-805 | Human | 1-170 | 12809519 | ||
TRPP2 |
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Troponin I 3 | Yeast two-hybrid | Human | 562-805 | Human | 106-158 | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPP2 |
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Troponin I 3 | Calcium measurement | Inhibition | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
