Troponin I 2 / TRP channels
Name: Troponin I, fast skeletal muscle
(Troponin I 2)
Official Symbol: TNNI2
provided by HGNC
Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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7136![]() |
P48788![]() |
DIP-44681N![]() |
MINT-3016990![]() |
112990![]() |
P48788![]() |
hsa:7136![]() |
191043![]() |
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Mouse
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21953![]() |
P13412![]() |
UNK-5371627![]() |
204265![]() |
P13412![]() |
mmu:21953![]() |
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Rat
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29389![]() |
P27768![]() |
MINT-1534490![]() |
248041![]() |
P27768![]() |
rno:29389![]() |
Biological Process:
- GO:0030049
: muscle filament sliding
- GO:0045893
: positive regulation of transcription, DNA-dependent
- GO:0003009
: skeletal muscle contraction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:191043
: Arthrogryposis multiplex congenita, distal, type 2B (OMIM:601680
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
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Troponin I 2 | Inference | Prediction | 12525172 | |||||
TRPP2 |
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Troponin I 2 | Inference | Prediction | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPP2 |
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Troponin I 2 | Fusion protein-pull down assay | Human | 562-805 | E. coli | Human | Not specified | Not specified | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
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Troponin I 2 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12525172 | |
TRPP1 |
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Troponin I 2 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12525172 | |
TRPP2 |
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Troponin I 2 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12809519 | |
TRPP2 |
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Troponin I 2 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
