Troponin I 1 / TRP channels
Name: Troponin I, slow skeletal muscle
(Troponin I 1)
Official Symbol: TNNI1
provided by HGNC
Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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7135![]() |
P19237![]() |
P19237![]() |
MINT-1467470![]() |
112989![]() |
P19237![]() |
hsa:7135![]() |
191042![]() |
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Mouse
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21952![]() |
Q9WUZ5![]() |
204264![]() |
Q9WUZ5![]() |
mmu:21952![]() |
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Rat
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29388![]() |
P13413![]() |
248040![]() |
P13413![]() |
rno:29388![]() |
Biological Process:
- GO:0030049
: muscle filament sliding
- GO:0006942
: regulation of striated muscle contraction
- GO:0055010
: ventricular cardiac muscle tissue morphogenesis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
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Troponin I 1 | Inference | Prediction | 12525172 | |||||
TRPP2 |
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Troponin I 1 | Inference | Prediction | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPP2 |
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Troponin I 1 | Fusion protein-pull down assay | Human | 562-805 | E. coli | Human | Not specified | Not specified | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
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Troponin I 1 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12525172 | |
TRPP1 |
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Troponin I 1 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12525172 | |
TRPP2 |
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Troponin I 1 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12809519 | |
TRPP2 |
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Troponin I 1 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPP2 |
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Troponin I 1 | Calcium measurement | Inhibition | 12809519 | |||||||
TRPP2 |
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Troponin I 1 | Patch clamp | Inhibition | 12809519 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
