Tropomyosin 1 / TRP channels
Name: Tropomyosin alpha-1 chain
(Tropomyosin 1)
Official Symbol: TPM1
provided by HGNC
Function:
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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7168![]() |
P09493![]() |
DIP-33125N![]() |
P09493![]() |
MINT-1150102![]() |
113021![]() |
P09493![]() |
hsa:7168![]() |
191010![]() |
|
Mouse
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22003![]() |
P58771![]() |
DIP-300N![]() |
P58771![]() |
MINT-149814![]() |
204291![]() |
P58771![]() |
mmu:22003![]() |
||
Rat
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24851![]() |
P04692![]() |
DIP-29020N![]() |
P04692![]() |
246968![]() |
P04692![]() |
rno:24851![]() |
PPI pairs:
Biological Process:
- GO:0060048
: cardiac muscle contraction
- GO:0034614
: cellular response to reactive oxygen species
- GO:0030049
: muscle filament sliding
- GO:0030336
: negative regulation of cell migration
- GO:0032781
: positive regulation of ATPase activity
- GO:0045785
: positive regulation of cell adhesion
- GO:0003065
: positive regulation of heart rate by epinephrine
- GO:0051496
: positive regulation of stress fiber assembly
- GO:0006937
: regulation of muscle contraction
- GO:0031529
: ruffle organization
- GO:0045214
: sarcomere organization
- GO:0055010
: ventricular cardiac muscle tissue morphogenesis
- GO:0042060
: wound healing
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:191010
: Cardiomyopathy, familial hypertrophic, 3 (OMIM:115196
)
- OMIM:191010
: Cardiomyopathy, dilated, 1Y (OMIM:611878
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
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Tropomyosin 1 | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library | 12527301 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPP1 |
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Tropomyosin 1 | Fusion protein-pull down assay | Human | 682-968 | E. coli | Human | Full-length | E. coli | 12527301 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
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Tropomyosin 1 | Co-immunofluorescence staining | NIH-3T3 | Human | Full-length | Human | Full-length | 12527301 | |
TRPP1 |
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Tropomyosin 1 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12527301 | |
TRPP1 |
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Tropomyosin 1 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12527301 | |
TRPP1 |
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Tropomyosin 1 | Co-immunoprecipitation | HEK293 | 12527301 | |||||
TRPP1 |
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Tropomyosin 1 | Co-immunoprecipitation | Human kidney tissue | 12527301 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
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Tropomyosin 1 | Yeast two-hybrid | Human | 821-878 | Human | 152-196 | 12527301 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
