TRPV1 / interactors

Name: Transient receptor potential cation channel subfamily V member 1 (TRPV1)
Official Symbol: TRPV1 provided by HGNC
Function:
Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
7442External Q8NER1External     MINT-4721979External 113281External Q8NER1External 507External hsa:7442External 602076External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
193034External Q704Y3External DIP-59791NExternal   MINT-5185032External 228724External Q704Y3External   mmu:193034External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
83810External O35433External DIP-46106NExternal O35433External MINT-5117510External 249845External O35433External   rno:83810External  
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 80K-H Speculation Prediction 19801576
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Actin Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Inference Prediction 18381233
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Akt Inference Prediction 21493704
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AMPKơ2 Inference Prediction 22451268
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Apolipoprotein O Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 BKca Inference Prediction 24147119
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Inference Prediction 12808128
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CaMKII Inference Prediction 21493704
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Catenin-ơ2 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Catenin-Ƥ2 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CB1 Inference Prediction 23142606
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Cbl Inference Prediction 19155296
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CDK12 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CDK5 Inference Prediction 17194758
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CHERP Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Contactin-1 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 DAP-150 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 DAZAP2 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 E-cadherin Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 E-cadherin Inference Prediction 23345400
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Eferin/Rab11-FIP3 Yeast two-hybrid Rat 684-820 Mouse Brain cDNA library 15883036
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 EGFR Inference Prediction 19155296
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 eNOS Inference Prediction 21493704
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 FAF1 Yeast two-hybrid Rat 243-440 Rat Sensory neuron cDNA expression library 16510717
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 GABARAP Yeast two-hybrid Rat 1-414 Rat Brain cDNA library 20179142
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 GCN5 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Glucose 6 phosphatase Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Glycogen phosphorylase Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-arrestin 2 Speculation Prediction 22952227
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-catenin Inference Prediction 23345400
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-tubulin-3 Inference Prediction 17298389
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-tubulin-5 Affinity purification-mass spectrometry Rat 681-838 Rat Spinal cord Extract 15569253
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HAX-1 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ITM2C Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 JMJD2C Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KCNQ2 Inference Prediction 21844219
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KCNQ3 Inference Prediction 21844219
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KIF13B Inference Prediction 23077056
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KIF2A Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KIF3B Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KPNƢ1 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KvƢ2 Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Neuronatin Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NKX2.2 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NMDAR1 Inference Prediction 22609428
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NMDAR2B Inference Prediction 22609428
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NOMO1 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ơ-tubulin-1A Inference Prediction 15569253
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ơ-tubulin-1B Inference Prediction 22262838
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ơENaC Inference Prediction 24890824
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ơII-spectrin Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 OS-9 Inference Prediction 17932042
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 P2RX3 Inference Prediction 19223122
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PACS-1 Inference Prediction 23159249
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PEX10 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PI3K-p85Ƣ Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PI3K-p85ơ Inference Prediction 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PIRT Inference Prediction 18455988
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKA Inference Prediction 12194871
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKARIIơ Inference Prediction 18463244
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKC Inference Prediction 14523239
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƢ Inference Prediction 24920628
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƥ Inference Prediction 11884385
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PLAGL1 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PLCƣ1 Inference Prediction 15744307
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 POLR2G Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 POLR3D Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PPARơ Inference Prediction 25014183
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PRKD1/PKCƬ Inference Prediction 15471852
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 RAB26 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 RAB8b Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 RANBP9 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ribosomal protein L9 Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 RPL12 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 RyR1 Affinity purification-mass spectrometry Not used as a bait Rabbit Fast-twitch muscle Triad vesicles 18215135
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SGT Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SMA3 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SNAPIN Yeast two-hybrid Rat 1-414 Rat Brain cDNA library 15066994
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SNAPIN Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 snRNP 70 Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC Inference Prediction 15084474
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Synaptotagmin 1 Inference Prediction 15066994
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Synaptotagmin 4 Yeast two-hybrid Rat 1-414 Rat Brain cDNA library 15066994
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TAK1 Inference Prediction 23142606
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TGS1 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Thrombospondin-3 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TMEM115 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TrkA Inference Prediction 11418861
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPA1 Inference Prediction 20231274
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Inference Prediction 15713749
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV3 Inference Prediction 12077606
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 UBP5 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ZBTB17 Yeast two-hybrid Rat 1-432 Human Fetal brain cDNA library 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ZO-1 Affinity purification-mass spectrometry Not used Mouse Dorsal root ganglion tissue Lysates 24036102
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Fusion protein-pull down assay Human 681-839 E. coli Not used HEK293 lysates 18701070
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Fast performance liquid chromatography Rat 759-802 E. coli Human Full-length E. coli 23109716
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Fast performance liquid chromatography Rat 712?838 E. coli Mouse Full-length E. coli 23119017
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Fusion protein-pull down assay Rat N-terminus E. coli Not specified Full-length In vitro translation 14699077
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Fusion protein-pull down assay Rat C-terminus E. coli Bovine Full-length Not specified 12808128
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin X-ray diffraction-structural analysis Rat 784-798 E. coli Human Full-length E. coli 23109716
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Cbl Fusion protein-pull down assay Not specified 680-838 HEK293 lysates Not used A431 Human epithelial carcinoma cell line 19155296
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Eferin/Rab11-FIP3 Fusion protein-pull down assay Rat Full-length HEK293T lysates Mouse Full-length E. coli 15883036
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 EGFR Fusion protein-pull down assay Not specified 680-838 HEK293 lysates Not used A431 Human epithelial carcinoma cell line 19155296
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 FAF1 Fusion protein-pull down assay Rat 1-440 E. coli Rat Full-length E. coli 16510717
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 GABARAP Fusion protein-pull down assay Not used Rat brain lysates Human Full-length E. coli 20179142
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-tubulin-3 Fusion protein-pull down assay Rat 681-838 E. coli Not used Pig brain tissue lysates 17298389
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-tubulin-5 Fusion protein-pull down assay Rat 681-838 E. coli Rat Full-length Rat spinal cord extract 15569253
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KIF13B Co-immunoprecipitation Rat Full-length CHO cell lysates Rat 1-557 E. coli 23077056
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ơ-tubulin-1A Fusion protein-pull down assay Rat 681-838 E. coli Rat Full-length Rat spinal cord extract 15569253
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PI3K-p85ơ Fusion protein-pull down assay Rat Full-length HEK293 lysates Not specified Full-length E. coli 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PLCƣ1 Yeast two-hybrid Rat 761-835 Yeast Rat 796-920 Yeast 15744307
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PRKD1/PKCƬ Fusion protein-pull down assay Rat Full-length E. coli Not specified Full-length Not specified 15471852
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SNAPIN Fusion protein-pull down assay Rat 1-414 E. coli Human Full-length In vitro translation 15066994
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Synaptotagmin 1 Fusion protein-pull down assay Rat 1-414 E. coli Human Full-length In vitro translation 15066994
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Synaptotagmin 4 Fusion protein-pull down assay Rat 1-414 E. coli Human Full-length In vitro translation 15066994
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 80K-H Co-immunoprecipitation HEK293T Human Full-length Human Full-length 19801576
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunofluorescence staining Rat trigeminal ganglia neuron 18381233
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunofluorescence staining Mouse dorsal root ganglion tissue 18463244
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunofluorescence staining Rat dorsal root ganglion neuron 18701070
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation Rat trigeminal ganglia neuron 22789851
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation Rat trigeminal ganglia neuron 18381233
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation CHO Rat Full-length Rat Full-length 18381233
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation Mouse spinalcord tissue 18463244
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation Mouse dorsal root ganglion tissue 18463244
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 23264624
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation HEK293 Human Full-length Mouse Full-length 23264624
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation Rat dorsal root ganglion neuron 18701070
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation HEK293 Human Full-length Not used 18701070
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Akt Co-immunoprecipitation Bovine aortic endothelial cells 21493704
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AMPKơ2 Co-immunoprecipitation Bovine aortic endothelial cells 22451268
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 BKca Co-immunofluorescence staining HEK293 Mouse Full-length Human Full-length 24147119
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 BKca Co-immunoprecipitation HEK293 Mouse Full-length Human Full-length 24147119
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 BKca Co-immunoprecipitation Rat dorsal root ganglion neuron 24147119
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Co-immunoprecipitation HEK293 Rat Full-length Rat Full-length 12808128
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CaMKII Co-immunoprecipitation Bovine aortic endothelial cells 21493704
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CB1 Co-immunofluorescence staining Mouse corneal epithelium section 23142606
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CB1 Co-immunofluorescence staining Human corneal epithelial cells 23142606
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CB1 Co-immunoprecipitation Human corneal epithelial cells 23142606
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 E-cadherin Co-immunofluorescence staining Rat SMG cell line (SMG-C6) 23345400
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 E-cadherin Co-immunoprecipitation Rat SMG cell line (SMG-C6) 23345400
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Eferin/Rab11-FIP3 Co-immunofluorescence staining HEK293T Rat Full-length Human Full-length 15883036
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Eferin/Rab11-FIP3 Co-immunoprecipitation HEK293T Rat Full-length Human Full-length 15883036
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 EGFR Co-immunoprecipitation HEK293 Not specified Full-length Not used 19155296
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 EGFR Co-immunoprecipitation HaCaT 19155296
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 eNOS Co-immunoprecipitation Bovine aortic endothelial cells 21493704
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 eNOS Co-immunoprecipitation Bovine aortic endothelial cells 22451268
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 eNOS Mammalian two-hybrid Bovine aortic endothelial cells Rat Full-length Human Full-length 22451268
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 FAF1 Co-immunofluorescence staining Rat dorsal root ganglion cell 16510717
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 FAF1 Co-immunoprecipitation Rat dorsal root ganglion cell 16510717
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 FAF1 Co-immunoprecipitation HEK293T Rat Full-length Rat Full-length 16510717
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 GABARAP Co-immunofluorescence staining Neonatal rat dorsal root ganglion 20179142
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 GABARAP Fluorescence resonance energy transfer HEK293 Rat Full-length Human Full-length 20179142
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-arrestin 2 Co-immunoprecipitation Rat trigeminal ganglia sensory neuron 22952227
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-arrestin 2 Co-immunoprecipitation Rat trigeminal (TG) ganglia 24695785
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-arrestin 2 Co-immunoprecipitation CHO Rat Full-length Bovine Full-length 23360390
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-catenin Co-immunofluorescence staining Rat SMG cell line (SMG-C6) 23345400
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-catenin Co-immunoprecipitation Rat SMG cell line (SMG-C6) 23345400
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-tubulin-5 Co-immunoprecipitation Rat dorsal root ganglion derived cell line F11 Rat Full-length Not used 15569253
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KCNQ2 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 21844219
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KCNQ3 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 21844219
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KIF13B Co-immunoprecipitation CHO (rTRPV1 stable cell) Not used Rat 1-557 23077056
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KIF13B Co-immunoprecipitation F11 Rat Full-length Rat 1-557 23077056
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KvƢ2 Co-immunofluorescence staining Mouse dorsal root ganglion neuron 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KvƢ2 Co-immunofluorescence staining HEK293 tsA 201 Mouse Full-length Not specified Not specified 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KvƢ2 Co-immunoprecipitation HEK293 tsA 201 Mouse Full-length Not specified Not specified 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NMDAR1 Co-immunofluorescence staining Rat trigeminal ganglia lysates 22609428
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NMDAR1 Co-immunoprecipitation Rat trigeminal ganglia lysates 22609428
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NMDAR2B Co-immunoprecipitation Rat trigeminal ganglia lysates 22609428
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ơ-tubulin-1B Fluorescence resonance energy transfer CHO Mouse Full-length Human Full-length 22262838
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ơENaC Co-immunofluorescence staining Mouse M1-cortical collecting duct 24890824
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ơENaC Co-immunoprecipitation Mouse M1-cortical collecting duct 24890824
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 OS-9 Co-immunoprecipitation HEK293T Mouse Full-length Mouse Full-length 17932042
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 P2RX3 Co-immunoprecipitation HEK293 Rat Full-length Human Full-length 19223122
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PACS-1 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 23159249
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PI3K-p85Ƣ Co-immunoprecipitation HEK293 Rat Full-length Not used 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PI3K-p85Ƣ Co-immunoprecipitation Mouse dorsal root ganglion cell 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PIRT Co-immunoprecipitation HEK293 Rat Full-length Mouse Full-length 18455988
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKARIIơ Co-immunoprecipitation Mouse spinalcord tissue 18463244
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƢ Co-immunofluorescence staining HEK293 Human Full-length Human Full-length 24920628
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƢ Co-immunofluorescence staining Rat dorsal root ganglion cell 24920628
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƢ Co-immunoprecipitation Rat dorsal root ganglion cell 24920628
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƢ Co-immunoprecipitation HEK293 Human Full-length Human Full-length 24920628
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PPARơ Co-immunoprecipitation CHO Rat Full-length Rat Full-length 25014183
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PRKD1/PKCƬ Co-immunofluorescence staining Rat dorsal root ganglion section 18063480
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PRKD1/PKCƬ Co-immunoprecipitation Rat dorsal root ganglion lysates 18063480
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PRKD1/PKCƬ Co-immunoprecipitation CHO Rat Full-length Human Full-length 15471852
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PRKD1/PKCƬ Co-immunoprecipitation Rat dorsal root ganglion neuron 15471852
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SNAPIN Co-immunoprecipitation HEK293 Human Full-length Human Full-length 15066994
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC Co-immunoprecipitation Rat dorsal root ganglion neuron 15084474
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC Co-immunoprecipitation HEK293 16319926
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Synaptotagmin 1 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 15066994
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Synaptotagmin 4 Co-immunofluorescence staining Rat dorsal root ganglion neuron 15066994
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Synaptotagmin 4 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 15066994
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TAK1 Co-immunoprecipitation Human corneal epithelial cells 23142606
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TrkA Co-immunoprecipitation HEK293 Rat Full-length Rat Full-length 11418861
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPA1 Co-immunoprecipitation CHO Rat Full-length Mouse Full-length 20231274
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPA1 Co-immunoprecipitation Mouse trigeminal ganglia lysates 20231274
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunofluorescence staining Rat dorsal root ganglion tissue 16115206
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunofluorescence staining HEK293 Rat Full-length Rat Full-length 16237318
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunofluorescence staining Rat dorsal root ganglion section 16237318
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunoprecipitation HEK293 Rat Full-length Rat Full-length 16115206
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunoprecipitation Rat brain cortical lysates 16115206
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 16237318
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunoprecipitation Rat dorsal root ganglion derived cell line F11 Rat Full-length Rat Full-length 16237318
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunoprecipitation Rat dorsal root ganglion lysates 16237318
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunoprecipitation Rat spinal cord lysates 16237318
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV2 Co-immunoprecipitation HEK293 Rat Full-length Mouse Full-length 15713749
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPV3 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 12077606
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Tubulin Co-immunofluorescence staining Rat supraoptic nucleus lysates 25123313
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Tubulin Co-immunoprecipitation Rat supraoptic nucleus lysates 25123313
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation Human Not determined Human 326-336 23699529
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation Human 736-749 Human Not determined 18701070
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Fluorescence resonance energy transfer Human Not determined Human 326-336 23699529
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Fusion protein-pull down assay Human 736-749 Human Not determined 18701070
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Patch clamp Human 738 ?745 Human Not determined 23616546
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Fast performance liquid chromatography Rat 712?838 Mouse Not determined 23119017
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Fusion protein-pull down assay Rat ARD domain Not specified Not determined 20926660
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Fusion protein-pull down assay Rat 189-222 Not specified Not determined 14699077
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Fusion protein-pull down assay Human 101-364 Not specified Not determined 19864432
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Fusion protein-pull down assay Rat 767-801 Bovine Not determined 12808128
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin X-ray diffraction-structural analysis Rat 784-798 Human 11-145 23109716
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Eferin/Rab11-FIP3 Yeast two-hybrid Rat 684-820 Mouse 345-444 15883036
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 FAF1 Fusion protein-pull down assay Rat 243-440 Rat 110-169 16510717
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 GABARAP Fusion protein-pull down assay Rat 1-414 Human 1-36 20179142
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-tubulin-3 Fusion protein-pull down assay Rat 681-730 Pig Not determined 17298389
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KCNQ2 Co-immunoprecipitation Human Not determined Human 97-318 21844219
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KCNQ2 Co-immunoprecipitation Human 1-684 Human Not determined 21844219
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KIF13B Cell surface biotinylation Rat Not determined Rat 455-557 23077056
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KIF13B Co-immunoprecipitation Rat Not determined Rat 455-557 23077056
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PI3K-p85ơ Fusion protein-pull down assay Rat N-terminus Not specified SH2 domain 17074976
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PIRT Co-immunoprecipitation Rat Not determined Mouse 110-135 18455988
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƢ Fusion protein-pull down assay Human 1-433 Human 341-673 24920628
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PLCƣ1 Yeast two-hybrid Rat 761-835 Rat 861-920 15744307
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PRKD1/PKCƬ Fusion protein-pull down assay Rat 99-118 Human Not determined 15471852
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC Fusion protein-pull down assay Human 1-433 Rat 83-144 16319926
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC Fusion protein-pull down assay Human 681-839 Rat 83-144 16319926
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Synaptotagmin 4 Fusion protein-pull down assay Rat 1-414 Human C2A domain 15066994
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Cell surface biotinylation Increase in plasma membrane level 18701070
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunofluorescence staining Increase in plasma membrane level 23699529
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Co-immunoprecipitation Increase in plasma membrane level 23616546
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 In vivo PTM assay Phosphorylation 18381233
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 AKAP5/AKAP150 Patch clamp Activation 18701070
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Patch clamp Inhibition 14699077
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Patch clamp Sensitization 23109716
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Calmodulin Patch clamp Inhibition 12808128
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CB1 Patch clamp Inhibition 23142606
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CDK5 Cell surface biotinylation Increase in plasma membrane level 23077056
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CDK5 In vitro PTM assay Phosphorylation (Thr-407) 17194758
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CDK5 In vitro PTM assay Phosphorylation 22451679
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 CDK5 In vivo PTM assay Phosphorylation (Thr-407) 17194758
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 FAF1 Calcium measurement Inhibition 16510717
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 FAF1 Patch clamp Inhibition 16510717
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 GABARAP Calcium measurement Inhibition 20179142
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 GABARAP Cell surface biotinylation Increase in plasma membrane level 20179142
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 GABARAP Patch clamp Inhibition 20179142
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-arrestin 2 Calcium measurement Desensitization 22952227
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Ƣ-arrestin 2 In vivo PTM assay Dephosphorylation 22952227
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KIF13B Cell surface biotinylation Increase in plasma membrane level 23077056
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 KvƢ2 Cell surface biotinylation Increase in plasma membrane level 24036102
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PIRT Patch clamp Activation 18455988
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKA In vitro PTM assay Phosphorylation (Ser-116) 12194871
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKA Patch clamp Activation 12194871
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKC In vitro PTM assay Phosphorylation 14523239
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƢ In vivo PTM assay Phosphorylation (Thr-705) 24920628
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƢ Patch clamp Activation 24920628
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƥ In vitro PTM assay Phosphorylation (Ser-800) 11884385
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƥ In vivo PTM assay Phosphorylation (Ser-502) 11884385
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKCƥ Patch clamp Activation 11884385
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PPARơ Calcium measurement Activation 25014183
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PPARơ Patch clamp Activation 25014183
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PRKD1/PKCƬ Calcium measurement Activation 15471852
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PRKD1/PKCƬ In vitro PTM assay Phosphorylation (Ser-116) 15471852
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC Calcium measurement Activation 16319926
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC In vitro PTM assay Phosphorylayion (Tyr-200) 16319926
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC In vivo PTM assay Phosphorylation 15084474
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC In vivo PTM assay Phosphorylayion (Tyr-200) 16319926
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC Patch clamp Activation 15084474
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SRC Patch clamp Activation 16319926
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TrkA In vivo PTM assay Phosphorylayion (Tyr-200) 16319926
TRPV1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TrkA Patch clamp Activation 16319926
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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