TMEM48/NDC1 / TRP channels
Name: Nucleoporin NDC1
(TMEM48/NDC1)
Official Symbol: TMEM48
provided by HGNC
Function:
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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55706![]() |
Q9BTX1![]() |
DIP-56707N![]() |
Q9BTX1![]() |
120831![]() |
Q9BTX1![]() |
hsa:55706![]() |
610115![]() |
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Mouse
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72787![]() |
Q8VCB1![]() |
DIP-56706N![]() |
Q8VCB1![]() |
215568![]() |
Q8VCB1![]() |
mmu:72787![]() |
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Rat
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362557![]() |
Q6AXN4![]() |
263536![]() |
Q6AXN4![]() |
rno:362557![]() |
PPI pairs:
Biological Process:
- GO:0051028
: mRNA transport
- GO:0051292
: nuclear pore complex assembly
- GO:0031081
: nuclear pore distribution
- GO:0015031
: protein transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
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TMEM48/NDC1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
