TAZ/WWTR1 / TRP channels
Name: WW domain-containing transcription regulator protein 1
(TAZ/WWTR1)
Official Symbol: WWTR1
provided by HGNC
Function:
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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25937![]() |
Q9GZV5![]() |
DIP-41925N![]() |
Q9GZV5![]() |
MINT-153572![]() |
117434![]() |
Q9GZV5![]() |
hsa:25937![]() |
607392![]() |
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Mouse
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97064![]() |
Q9EPK5![]() |
DIP-39476N![]() |
Q9EPK5![]() |
MINT-4123841![]() |
220584![]() |
Q9EPK5![]() |
mmu:97064![]() |
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Rat
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295062![]() |
Q4V7E6![]() |
UNK-5427078![]() |
254869![]() |
Q4V7E6![]() |
rno:295062![]() |
PPI pairs:
Biological Process:
- GO:0060271
: cilium morphogenesis
- GO:0032835
: glomerulus development
- GO:0035329
: hippo signaling cascade
- GO:0090090
: negative regulation of canonical Wnt receptor signaling pathway
- GO:0035414
: negative regulation of catenin import into nucleus
- GO:0045599
: negative regulation of fat cell differentiation
- GO:0006469
: negative regulation of protein kinase activity
- GO:0000122
: negative regulation of transcription from RNA polymerase II promoter
- GO:0001649
: osteoblast differentiation
- GO:0008284
: positive regulation of cell proliferation
- GO:0010718
: positive regulation of epithelial to mesenchymal transition
- GO:0045944
: positive regulation of transcription from RNA polymerase II promoter
- GO:0060390
: regulation of SMAD protein import into nucleus
- GO:0017145
: stem cell division
- GO:0006367
: transcription initiation from RNA polymerase II promoter
- GO:0007179
: transforming growth factor beta receptor signaling pathway
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
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TAZ/WWTR1 | Inference | Prediction | 17636028 |
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPP1 |
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TAZ/WWTR1 | Fusion protein-pull down assay | Mouse | 678-966 | E. coli | Mouse | 1-395 | HEK293 lysates | 17636028 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
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TAZ/WWTR1 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Mouse | Full-length | 17636028 | |
TRPP1 |
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TAZ/WWTR1 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell | 17636028 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPP1 |
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TAZ/WWTR1 | Fusion protein-pull down assay | Mouse | 678-966 | Mouse | 220-272 | 17636028 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
