TAZ/WWTR1 / TRP channels

Name: WW domain-containing transcription regulator protein 1 (TAZ/WWTR1)
Official Symbol: WWTR1 provided by HGNC
Function:
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
25937External Q9GZV5External DIP-41925NExternal Q9GZV5External MINT-153572External 117434External Q9GZV5External   hsa:25937External 607392External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
97064External Q9EPK5External DIP-39476NExternal Q9EPK5External MINT-4123841External 220584External Q9EPK5External   mmu:97064External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
295062External Q4V7E6External     UNK-5427078External 254869External Q4V7E6External   rno:295062External  
PPI pairs:
Biological Process:
  • GO:0060271 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : cilium morphogenesis
  • GO:0032835 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : glomerulus development
  • GO:0035329 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : hippo signaling cascade
  • GO:0090090 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of canonical Wnt receptor signaling pathway
  • GO:0035414 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of catenin import into nucleus
  • GO:0045599 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of fat cell differentiation
  • GO:0006469 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of protein kinase activity
  • GO:0000122 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : negative regulation of transcription from RNA polymerase II promoter
  • GO:0001649 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : osteoblast differentiation
  • GO:0008284 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of cell proliferation
  • GO:0010718 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of epithelial to mesenchymal transition
  • GO:0045944 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of transcription from RNA polymerase II promoter
  • GO:0060390 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : regulation of SMAD protein import into nucleus
  • GO:0017145 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : stem cell division
  • GO:0006367 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : transcription initiation from RNA polymerase II promoter
  • GO:0007179 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : transforming growth factor beta receptor signaling pathway
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TAZ/WWTR1 Inference Prediction 17636028
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TAZ/WWTR1 Fusion protein-pull down assay Mouse 678-966 E. coli Mouse 1-395 HEK293 lysates 17636028
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TAZ/WWTR1 Co-immunoprecipitation HEK293 Mouse Full-length Mouse Full-length 17636028
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TAZ/WWTR1 Co-immunoprecipitation Mouse Inner medullary collecting duct cell 17636028
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TAZ/WWTR1 Fusion protein-pull down assay Mouse 678-966 Mouse 220-272 17636028
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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