SUR1/ABCC8 / TRP channels
Name: ATP-binding cassette sub-family C member 8
(SUR1/ABCC8)
Official Symbol: ABCC8
provided by HGNC
Function:
Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
![]() |
6833![]() |
Q09428![]() |
DIP-58642N![]() |
112700![]() |
Q09428![]() |
hsa:6833![]() |
600509![]() |
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Mouse
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20927![]() |
B2RUS7![]() |
DIP-58644N![]() |
203577![]() |
mmu:20927![]() |
|||||
Rat
![]() |
25559![]() |
Q09429![]() |
247590![]() |
rno:25559![]() |
PPI pairs:
Biological Process:
- GO:0006200
: ATP catabolic process
- GO:0005975
: carbohydrate metabolic process
- GO:0006112
: energy reserve metabolic process
- GO:0050796
: regulation of insulin secretion
- GO:0007268
: synaptic transmission
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:600509
: Hyperinsulinemic hypoglycemia, familial, 1 (OMIM:256450
)
- OMIM:600509
: Hypoglycemia of infancy, leucine-sensitive (OMIM:240800
)
- OMIM:600509
: Diabetes mellitus, transient neonatal 2 (OMIM:610374
)
- OMIM:600509
: Diabetes mellitus, noninsulin-dependent (OMIM:125853
)
- OMIM:600509
: Diabetes mellitus, permanent neonatal (OMIM:606176
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPM4 |
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SUR1/ABCC8 | Inference | Prediction | 23255597 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPM4 |
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SUR1/ABCC8 | Co-immunoprecipitation | COS-7 | Mouse | Full-length | Not specified | Not specified | 23255597 | |
TRPM4 |
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SUR1/ABCC8 | Co-immunoprecipitation | Rat subarachnoid hemorrhage | 24114458 | |||||
TRPM4 |
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SUR1/ABCC8 | Fluorescence resonance energy transfer | COS-7 | Mouse | Full-length | Not specified | Not specified | 23255597 | |
TRPM4 |
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SUR1/ABCC8 | Fluorescence resonance energy transfer | COS-7 | 24114458 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
