SUR1/ABCC8 / TRP channels
Name: ATP-binding cassette sub-family C member 8
(SUR1/ABCC8)
Official Symbol: ABCC8
provided by HGNC
Function:
Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
6833 |
Q09428 |
DIP-58642N |
112700 |
Q09428 |
hsa:6833 |
600509 |
|||
|
Mouse
|
20927 |
B2RUS7 |
DIP-58644N |
203577 |
mmu:20927 |
|||||
|
Rat
|
25559 |
Q09429 |
247590 |
rno:25559 |
||||||
PPI pairs:
Biological Process:
- GO:0006200
: ATP catabolic process - GO:0005975 : carbohydrate metabolic process
- GO:0006112 : energy reserve metabolic process
- GO:0050796 : regulation of insulin secretion
- GO:0007268 : synaptic transmission
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:600509
:
Hyperinsulinemic hypoglycemia, familial, 1
(OMIM:256450 )
- OMIM:600509
:
Hypoglycemia of infancy, leucine-sensitive
(OMIM:240800 )
- OMIM:600509
:
Diabetes mellitus, transient neonatal 2
(OMIM:610374 )
- OMIM:600509
:
Diabetes mellitus, noninsulin-dependent
(OMIM:125853 )
- OMIM:600509
:
Diabetes mellitus, permanent neonatal
(OMIM:606176 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPM4 |
|
SUR1/ABCC8 | Inference | Prediction | 23255597 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPM4 |
|
SUR1/ABCC8 | Co-immunoprecipitation | COS-7 | Mouse | Full-length | Not specified | Not specified | 23255597 | |
| TRPM4 |
|
SUR1/ABCC8 | Co-immunoprecipitation | Rat subarachnoid hemorrhage | 24114458 | |||||
| TRPM4 |
|
SUR1/ABCC8 | Fluorescence resonance energy transfer | COS-7 | Mouse | Full-length | Not specified | Not specified | 23255597 | |
| TRPM4 |
|
SUR1/ABCC8 | Fluorescence resonance energy transfer | COS-7 | 24114458 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)