Ribophorin II / TRP channels
Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
(Ribophorin II)
Official Symbol: RPN2
provided by HGNC
Function:
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
6185 |
P04844 |
DIP-38153N |
P04844 |
MINT-8247596 |
112100 |
P04844 |
hsa:6185 |
180490 |
|
|
Mouse
|
20014 |
Q9DBG6 |
DIP-32105N |
Q9DBG6 |
MINT-1859656 |
202990 |
Q9DBG6 |
mmu:20014 |
||
|
Rat
|
64701 |
P25235 |
DIP-37304N |
P25235 |
MINT-4996562 |
249196 |
P25235 |
rno:64701 |
||
PPI pairs:
Biological Process:
- GO:0043687
: post-translational protein modification - GO:0018279 : protein N-linked glycosylation via asparagine
- GO:0006614 : SRP-dependent cotranslational protein targeting to membrane
- GO:0006412 : translation
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
Ribophorin II | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)