Pyruvate kinase M1/M2 / TRP channels
Name: Pyruvate kinase isozymes M1/M2
(Pyruvate kinase M1/M2)
Official Symbol: PKM
provided by HGNC
Function:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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5315![]() |
P14618![]() |
P14618![]() |
MINT-4998892![]() |
111332![]() |
P14618![]() |
hsa:5315![]() |
179050![]() |
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Mouse
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18746![]() |
P52480![]() |
P52480![]() |
MINT-1850796![]() |
202191![]() |
P52480![]() |
mmu:18746![]() |
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Rat
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25630![]() |
P11980![]() |
P11980![]() |
MINT-4587504![]() |
247659![]() |
P11980![]() |
rno:25630![]() |
PPI pairs:
Biological Process:
- GO:0006754
: ATP biosynthetic process
- GO:0006096
: glycolysis
- GO:0001889
: liver development
- GO:0031100
: organ regeneration
- GO:0012501
: programmed cell death
- GO:0042866
: pyruvate biosynthetic process
- GO:0009629
: response to gravity
- GO:0001666
: response to hypoxia
- GO:0032868
: response to insulin stimulus
- GO:0014870
: response to muscle inactivity
- GO:0007584
: response to nutrient
- GO:0043403
: skeletal muscle tissue regeneration
- GO:0044281
: small molecule metabolic process
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 |
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Pyruvate kinase M1/M2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
