Protein 4.1 / TRP channels
Name: Protein 4.1
(Protein 4.1)
Official Symbol: EPB41
provided by HGNC
Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
![]() |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
![]() |
2035![]() |
P11171![]() |
DIP-17032N![]() |
P11171![]() |
MINT-1208648![]() |
108349![]() |
P11171![]() |
hsa:2035![]() |
130500![]() |
|
Mouse
![]() |
269587![]() |
P48193![]() |
DIP-41958N![]() |
MINT-149787![]() |
234673![]() |
P48193![]() |
mmu:269587![]() |
|||
Rat | 313052![]() |
260307![]() |
rno:313052![]() |
Biological Process:
- GO:0030036
: actin cytoskeleton organization
- GO:0008015
: blood circulation
- GO:0030866
: cortical actin cytoskeleton organization
- GO:0032092
: positive regulation of protein binding
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:130500
: Elliptocytosis-1 (OMIM:611804
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
![]() ![]() ![]() ![]() ![]() |
![]() |
Screening
![]() |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC1 |
![]() |
Protein 4.1 | Inference | Prediction | 22534489 | |||||
TRPC4 |
![]() |
Protein 4.1 | Inference | Prediction | 16254212 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

![]() ![]() ![]() ![]() ![]() |
![]() |
Validation: In vivo validation
![]() |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC1 |
![]() |
Protein 4.1 | Co-immunoprecipitation | Rat pumonary aortic endothelial cell | 22534489 | |||||
TRPC4 |
![]() |
Protein 4.1 | Co-immunoprecipitation | Rat pumonary aortic endothelial cell | 16254212 | |||||
TRPC4 |
![]() |
Protein 4.1 | Co-immunoprecipitation | Rat pumonary aortic endothelial cell | 22534489 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

![]() ![]() ![]() ![]() ![]() |
![]() |
Functional consequence
![]() |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPC4 |
![]() |
Protein 4.1 | Calcium measurement | Activation | 16254212 | |||||||
TRPC4 |
![]() |
Protein 4.1 | Patch clamp | Activation | 16254212 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
