PDIA3/GRP58 / TRP channels
Name: Protein disulfide-isomerase A3
(PDIA3/GRP58)
Official Symbol: PDIA3
provided by HGNC
Function:
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
2923 |
P30101 |
DIP-29132N |
P30101 |
MINT-5000005 |
109180 |
P30101 |
hsa:2923 |
602046 |
|
|
Mouse
|
14827 |
P27773 |
DIP-38094N |
P27773 |
MINT-4590033 |
200077 |
P27773 |
mmu:14827 |
||
|
Rat
|
29468 |
P11598 |
DIP-37040N |
P11598 |
MINT-4575564 |
248111 |
P11598 |
rno:29468 |
||
PPI pairs:
Biological Process:
- GO:0002479
: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent - GO:0045454 : cell redox homeostasis
- GO:0006662 : glycerol ether metabolic process
- GO:0043065 : positive regulation of apoptotic process
- GO:0043687 : post-translational protein modification
- GO:0006606 : protein import into nucleus
- GO:0018279 : protein N-linked glycosylation via asparagine
- GO:0006621 : protein retention in ER lumen
- GO:0007165 : signal transduction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
|
Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
PDIA3/GRP58 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)