M1 mAChR / TRP channels
Name: Muscarinic acetylcholine receptor M1
(M1 mAChR)
Official Symbol: CHRM1
provided by HGNC
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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1128![]() |
P11229![]() |
DIP-56279N![]() |
P11229![]() |
MINT-7970464![]() |
107550![]() |
P11229![]() |
hsa:1128![]() |
118510![]() |
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Mouse
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12669![]() |
P12657![]() |
198706![]() |
P12657![]() |
mmu:12669![]() |
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Rat
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25229![]() |
P08482![]() |
247270![]() |
P08482![]() |
rno:25229![]() |
PPI pairs:
Biological Process:
- GO:0008283
: cell proliferation
- GO:0006464
: cellular protein modification process
- GO:0007399
: nervous system development
- GO:0007274
: neuromuscular synaptic transmission
- GO:0007207
: phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- GO:0008284
: positive regulation of cell proliferation
- GO:0043270
: positive regulation of ion transport
- GO:0007205
: protein kinase C-activating G-protein coupled receptor signaling pathway
- GO:0040012
: regulation of locomotion
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC6 |
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M1 mAChR | Inference | Prediction | 15994335 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC6 |
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M1 mAChR | Co-immunoprecipitation | PC12D | 15994335 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPC6 |
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M1 mAChR | Calcium measurement | Activation | 15994335 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
