LAP2/TMPO / TRP channels
Name: Lamina-associated polypeptide 2, isoform alpha
(LAP2/TMPO)
Official Symbol: TMPO
provided by HGNC
Function:
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
![]() |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
![]() |
7112![]() |
P42166![]() |
DIP-32916N![]() |
P42166![]() |
MINT-2863664![]() |
112967![]() |
P42166![]() |
hsa:7112![]() |
188380![]() |
|
Mouse
![]() |
21917![]() |
Q61033![]() |
DIP-29323N![]() |
Q61033![]() |
MINT-4100192![]() |
204234![]() |
Q61033![]() |
mmu:21917![]() |
||
Rat
![]() |
25359![]() |
Q62733![]() |
MINT-4997319![]() |
247398![]() |
Q62733![]() |
rno:25359![]() |
PPI pairs:
Biological Process:
- GO:0006355
: regulation of transcription, DNA-dependent
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:188380
: Cardiomyopathy, dilated, 1T (OMIM:613740
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
![]() ![]() ![]() ![]() ![]() |
![]() |
Screening
![]() |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPP1 |
![]() |
LAP2/TMPO | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
