HSP40/DNAJB1 / TRP channels

Name: DnaJ homolog subfamily B member 1 (HSP40/DNAJB1)
Official Symbol: DNAJB1 provided by HGNC
Function:
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
3337External P25685External DIP-41180NExternal P25685External MINT-204558External 109569External P25685External   hsa:3337External 604572External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
81489External Q9QYJ3External   Q9QYJ3External MINT-4093206External 219875External Q9QYJ3External   mmu:81489External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
  B0K030External         B0K030External      
PPI pairs:
Biological Process:
  • GO:0070389 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : chaperone cofactor-dependent protein refolding
  • GO:0051085 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : chaperone mediated protein folding requiring cofactor
  • GO:0006986 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : response to unfolded protein
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSP40/DNAJB1 Affinity purification-mass spectrometry Mouse Full-length Mouse RAW264.7 macrophages Lysates 23418601
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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