Glucose 6 phosphatase / TRP channels
Name: Glucose-6-phosphatase 3
(Glucose 6 phosphatase)
Official Symbol: G6PC3
provided by HGNC
Function:
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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92579![]() |
Q9BUM1![]() |
124957![]() |
Q9BUM1![]() |
hsa:92579![]() |
611045![]() |
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Mouse
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68401![]() |
Q6NSQ9![]() |
212839![]() |
Q6NSQ9![]() |
mmu:68401![]() |
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Rat
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303565![]() |
Q6AZ83![]() |
257587![]() |
Q6AZ83![]() |
rno:303565![]() |
PPI pairs:
Biological Process:
- GO:0005975
: carbohydrate metabolic process
- GO:0016311
: dephosphorylation
- GO:0006094
: gluconeogenesis
- GO:0051156
: glucose 6-phosphate metabolic process
- GO:0015758
: glucose transport
- GO:0015760
: glucose-6-phosphate transport
- GO:0044281
: small molecule metabolic process
- GO:0055085
: transmembrane transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:611045
: Neutropenia, severe congenital 4, autosomal recessive (OMIM:612541
)
- OMIM:611045
: Darsun syndrome (OMIM:612541
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPV1 |
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Glucose 6 phosphatase | Affinity purification-mass spectrometry | Not used | Mouse | Dorsal root ganglion tissue | Lysates | 24036102 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
