Eferin/Rab11-FIP3 / TRP channels
Name: Rab11 family-interacting protein 3
(Eferin/Rab11-FIP3)
Official Symbol: RAB11FIP3
provided by HGNC
Function:
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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9727![]() |
O75154![]() |
DIP-47494N![]() |
MINT-6799564![]() |
115076![]() |
O75154![]() |
hsa:9727![]() |
608738![]() |
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Mouse
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215445![]() |
Q8CHD8![]() |
229626![]() |
Q8CHD8![]() |
mmu:215445![]() |
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Rat | 303002![]() |
257380![]() |
rno:303002![]() |
PPI pairs:
Biological Process:
- GO:0007049
: cell cycle
- GO:0000910
: cytokinesis
- GO:0032456
: endocytic recycling
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPV1 |
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Eferin/Rab11-FIP3 | Yeast two-hybrid | Rat | 684-820 | Mouse | Brain | cDNA library | 15883036 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPV1 |
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Eferin/Rab11-FIP3 | Fusion protein-pull down assay | Rat | Full-length | HEK293T lysates | Mouse | Full-length | E. coli | 15883036 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPV1 |
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Eferin/Rab11-FIP3 | Co-immunofluorescence staining | HEK293T | Rat | Full-length | Human | Full-length | 15883036 | |
TRPV1 |
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Eferin/Rab11-FIP3 | Co-immunoprecipitation | HEK293T | Rat | Full-length | Human | Full-length | 15883036 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPV1 |
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Eferin/Rab11-FIP3 | Yeast two-hybrid | Rat | 684-820 | Mouse | 345-444 | 15883036 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
