Dynamin-1 heavy chain 1 / TRP channels
Name: Cytoplasmic dynein 1 heavy chain 1
(Dynamin-1 heavy chain 1)
Official Symbol: DYNC1H1
provided by HGNC
Function:
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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1778![]() |
Q14204![]() |
Q14204![]() |
MINT-5003694![]() |
108117![]() |
Q14204![]() |
hsa:1778![]() |
600112![]() |
||
Mouse
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13424![]() |
Q9JHU4?![]() |
Q9JHU4?![]() |
Q9JHU4?![]() |
mmu:13424![]() |
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Rat
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29489![]() |
P38650![]() |
P38650![]() |
MINT-4564742![]() |
248131![]() |
P38650![]() |
rno:29489![]() |
PPI pairs:
Biological Process:
- GO:0019886
: antigen processing and presentation of exogenous peptide antigen via MHC class II
- GO:0008219
: cell death
- GO:0033962
: cytoplasmic mRNA processing body assembly
- GO:0000086
: G2/M transition of mitotic cell cycle
- GO:0007018
: microtubule-based movement
- GO:0007052
: mitotic spindle organization
- GO:0034063
: stress granule assembly
- GO:0006810
: transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:600112
: Charcot-Marie-Tooth disease, axonal, type 20 (OMIM:614228
)
- OMIM:600112
: Mental retardation, autosomal dominant 13 (OMIM:614563
)
- OMIM:600112
: Spinal muscular atrophy, lower extremity, autosomal dominant (OMIM:158600
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 |
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Dynamin-1 heavy chain 1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC3 |
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Dynamin-1 heavy chain 1 | Co-immunoprecipitation | Rat brain lysates | 18205297 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
