Dynamin-1 heavy chain 1 / TRP channels
Name: Cytoplasmic dynein 1 heavy chain 1
(Dynamin-1 heavy chain 1)
Official Symbol: DYNC1H1
provided by HGNC
Function:
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
1778 |
Q14204 |
Q14204 |
MINT-5003694 |
108117 |
Q14204 |
hsa:1778 |
600112 |
||
|
Mouse
|
13424 |
Q9JHU4? |
Q9JHU4? |
Q9JHU4? |
mmu:13424 |
|||||
|
Rat
|
29489 |
P38650 |
P38650 |
MINT-4564742 |
248131 |
P38650 |
rno:29489 |
|||
PPI pairs:
Biological Process:
- GO:0019886
: antigen processing and presentation of exogenous peptide antigen via MHC class II - GO:0008219 : cell death
- GO:0033962 : cytoplasmic mRNA processing body assembly
- GO:0000086 : G2/M transition of mitotic cell cycle
- GO:0007018 : microtubule-based movement
- GO:0007052 : mitotic spindle organization
- GO:0034063 : stress granule assembly
- GO:0006810 : transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:600112
:
Charcot-Marie-Tooth disease, axonal, type 20
(OMIM:614228 )
- OMIM:600112
:
Mental retardation, autosomal dominant 13
(OMIM:614563 )
- OMIM:600112
:
Spinal muscular atrophy, lower extremity, autosomal dominant
(OMIM:158600 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
Dynamin-1 heavy chain 1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC3 |
|
Dynamin-1 heavy chain 1 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)