Cytochrome c oxidase 2 / TRP channels
Name: Cytochrome c oxidase subunit 2
(Cytochrome c oxidase 2)
Official Symbol: MT-CO2
provided by HGNC
Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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4513![]() |
P00403![]() |
P00403![]() |
110616![]() |
P00403![]() |
hsa:4513![]() |
516040![]() |
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Mouse
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17709![]() |
P00405![]() |
P00405![]() |
201542![]() |
P00405![]() |
mmu:17709![]() |
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Rat
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P00406![]() |
MINT-4996308![]() |
P00406![]() |
PPI pairs:
Biological Process:
- GO:0007595
: lactation
- GO:0006123
: mitochondrial electron transport, cytochrome c to oxygen
- GO:0009409
: response to cold
- GO:0044281
: small molecule metabolic process
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 |
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Cytochrome c oxidase 2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
