Cyclophilin B / TRP channels
Name: Peptidyl-prolyl cis-trans isomerase B
(Cyclophilin B)
Official Symbol: PPIB
provided by HGNC
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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5479![]() |
P23284![]() |
DIP-50116N![]() |
P23284![]() |
MINT-1142578![]() |
111475![]() |
P23284![]() |
hsa:5479![]() |
123841![]() |
|
Mouse
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19035![]() |
P24369![]() |
DIP-34121N![]() |
P24369![]() |
MINT-1853937![]() |
202328![]() |
P24369![]() |
mmu:19035![]() |
||
Rat
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64367![]() |
P24368![]() |
DIP-37300N![]() |
P24368![]() |
MINT-4566333![]() |
249051![]() |
P24368![]() |
rno:64367![]() |
Biological Process:
- GO:0030198
: extracellular matrix organization
- GO:0006457
: protein folding
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:123841
: Osteogenesis imperfecta, type IX (OMIM:259440
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPV5 |
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Cyclophilin B | Inference | Prediction | 18445599 | |||||
TRPV6 |
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Cyclophilin B | Affinity purification-mass spectrometry | Human | 1-725 | Human | Placenta | Microsomal membrane fraction | 18445599 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPV6 |
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Cyclophilin B | Co-immunofluorescence staining | Xenopus oocyte | Human | Full-length | Human | Full-length | 18445599 | |
TRPV6 |
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Cyclophilin B | Co-immunofluorescence staining | Human placenta | 18445599 | |||||
TRPV6 |
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Cyclophilin B | Co-immunoprecipitation | Human placenta | 18445599 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPV5 |
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Cyclophilin B | Calcium measurement | Activation | 18445599 | |||||||
TRPV6 |
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Cyclophilin B | Calcium measurement | Activation | 18445599 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
