Apolipoprotein O / TRP channels
Name: Apolipoprotein O
(Apolipoprotein O)
Official Symbol: APOO
provided by HGNC
Function:
Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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79135![]() |
Q9BUR5![]() |
122556![]() |
Q9BUR5![]() |
hsa:79135![]() |
300753![]() |
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Mouse
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68316![]() |
Q9DCZ4![]() |
212802![]() |
mmu:68316![]() |
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Rat |
PPI pairs:
Biological Process:
- GO:0006869
: lipid transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPV1 |
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Apolipoprotein O | Affinity purification-mass spectrometry | Not used | Mouse | Dorsal root ganglion tissue | Lysates | 24036102 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
