Annexin 1 / TRP channels
Name: Annexin A1
(Annexin 1)
Official Symbol: ANXA1
provided by HGNC
Function:
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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301![]() |
P04083![]() |
DIP-32875N![]() |
P04083![]() |
MINT-1212274![]() |
106798![]() |
P04083![]() |
hsa:301![]() |
151690![]() |
|
Mouse
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16952![]() |
P10107![]() |
DIP-41769N![]() |
P10107![]() |
MINT-274958![]() |
201194![]() |
P10107![]() |
mmu:16952![]() |
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Rat
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25380![]() |
P07150![]() |
DIP-36938N![]() |
P07150![]() |
MINT-4542587![]() |
247419![]() |
P07150![]() |
rno:25380![]() |
PPI pairs:
Biological Process:
- GO:0046632
: alpha-beta T cell differentiation
- GO:0050482
: arachidonic acid secretion
- GO:0007049
: cell cycle
- GO:0007166
: cell surface receptor signaling pathway
- GO:0006928
: cellular component movement
- GO:0071385
: cellular response to glucocorticoid stimulus
- GO:0070301
: cellular response to hydrogen peroxide
- GO:0031018
: endocrine pancreas development
- GO:0060206
: estrous cycle phase
- GO:0042063
: gliogenesis
- GO:0070365
: hepatocyte differentiation
- GO:0006954
: inflammatory response
- GO:0030073
: insulin secretion
- GO:0030216
: keratinocyte differentiation
- GO:0002674
: negative regulation of acute inflammatory response
- GO:0043066
: negative regulation of apoptotic process
- GO:0050709
: negative regulation of protein secretion
- GO:0097350
: neutrophil clearance
- GO:0018149
: peptide cross-linking
- GO:0043065
: positive regulation of apoptotic process
- GO:0031394
: positive regulation of prostaglandin biosynthetic process
- GO:0031340
: positive regulation of vesicle fusion
- GO:0042127
: regulation of cell proliferation
- GO:0042493
: response to drug
- GO:0032355
: response to estradiol stimulus
- GO:0070555
: response to interleukin-1
- GO:0043434
: response to peptide hormone stimulus
- GO:0010165
: response to X-ray
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPM7 |
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Annexin 1 | Inference | Prediction | 15485879 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPM7 |
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Annexin 1 | Co-immunofluorescence staining | HEK293 | Human | ChaK1 domain | Human | Not determined | 24939696 | |
TRPM7 |
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Annexin 1 | Co-immunoprecipitation | HEK293 | Human | ChaK1 domain | Human | Not determined | 24939696 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPM7 |
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Annexin 1 | In vitro PTM assay | Human | ChaK1 domain | Human | Not determined | 15485879 | ||
TRPM7 |
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Annexin 1 | In vitro PTM assay | Human | ChaK1 domain | Bovine | Not determined | 15485879 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
