TRPV6 / TRPC1
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Screening
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Experimental screening | Non-experimental screening | Reference | |||||||
TRP channel construct | Interactor source | ||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
TRPV6 | TRPC1 | Inference | Prediction | 22932896 |
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | |||
TRPV6 | TRPC1 | Co-immunoprecipitation | HEK293 | Rat | Full-length | Human | Full-length | 22932896 | |
TRPV6 | TRPC1 | Co-immunoprecipitation | LNCaP | 25172921 | |||||
TRPV6 | TRPC1 | Fluorescence resonance energy transfer | HEK293 | Rat | Full-length | Human | Full-length | 22932896 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
TRP channel | Interactor | ||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | |||
TRPV6 | TRPC1 | Fluorescence resonance energy transfer | Rat | 1-198 | Human | 1-193 | 22932896 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
TRPV6 | TRPC1 | Cell surface biotinylation | Retain in the endoplasmic reticulum | 22932896 | |||||||
TRPV6 | TRPC1 | Patch clamp | Inhibition | 22932896 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
