TRPV6 / TRPC1
Interaction:
TRPV6
/
TRPC1
/
TRPC1
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPV6 | TRPC1 | Inference | Prediction | 22932896 | |||||
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:
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:
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|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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| Validation: In vivo validation
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| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPV6 | TRPC1 | Co-immunoprecipitation | HEK293 | Rat | Full-length | Human | Full-length | 22932896 | |
| TRPV6 | TRPC1 | Co-immunoprecipitation | LNCaP | 25172921 | |||||
| TRPV6 | TRPC1 | Fluorescence resonance energy transfer | HEK293 | Rat | Full-length | Human | Full-length | 22932896 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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|
| Characterization
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|---|---|---|---|---|---|---|---|---|---|
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
| TRP channel | Interactor | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPV6 | TRPC1 | Fluorescence resonance energy transfer | Rat | 1-198 | Human | 1-193 | 22932896 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Functional consequence
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| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
| TRPV6 | TRPC1 | Cell surface biotinylation | Retain in the endoplasmic reticulum | 22932896 | |||||||
| TRPV6 | TRPC1 | Patch clamp | Inhibition | 22932896 | |||||||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)