TRPV5 / Calmodulin
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Screening
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Experimental screening | Non-experimental screening | Reference | |||||||
TRP channel construct | Interactor source | ||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
TRPV5 | Calmodulin | Inference | Prediction | 15123711 |
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | ||||||||
TRP channel construct | Interactor construct | ||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | |
TRPV5 | Calmodulin | Fusion protein-pull down assay | Mouse | Full-length | In vitro translation | Not specified | Full-length | Not specified | 15123711 |
TRPV5 | Calmodulin | Fusion protein-pull down assay | Mouse | 1-327 | In vitro translation | Not specified | Full-length | Not specified | 15123711 |
TRPV5 | Calmodulin | Fusion protein-pull down assay | Mouse | 578-730 | In vitro translation | Not specified | Full-length | Not specified | 15123711 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
TRP channel | Interactor | ||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | |||
TRPV5 | Calmodulin | Fluorescence probe labeling | Human | 587-616 | Not specified | Not determined | 306 nM | 20686800 | |
TRPV5 | Calmodulin | Fusion protein-pull down assay | Human | ARD domain | Not specified | Not determined | 20926660 | ||
TRPV5 | Calmodulin | Fusion protein-pull down assay | Human | 696-729 | Not specified | Not determined | 21576356 | ||
TRPV5 | Calmodulin | Native-gel electrophoresis | Human | 696-729 | Not specified | Not determined | 21576356 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
TRPV5 | Calmodulin | Calcium measurement | Inhibition | 21576356 | |||||||
TRPV5 | Calmodulin | Patch clamp | Inhibition | 21576356 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
