TRPV4 / MAP7

Interaction: TRPV4Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c / MAP7Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPV4 MAP7 Yeast two-hybrid Mouse 783-871 Mouse Kidney cDNA library 14517216
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPV4 MAP7 Fusion protein-pull down assay Mouse Full-length HEK293 lysates Mouse Full-length In vitro translation 14517216
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPV4 MAP7 Co-immunofluorescence staining Mouse lung section 14517216
TRPV4 MAP7 Co-immunofluorescence staining Mouse kidney section 14517216
TRPV4 MAP7 Co-immunofluorescence staining HEK293 Mouse Full-length Mouse Full-length 14517216
TRPV4 MAP7 Co-immunoprecipitation Mouse renal tissue 14517216
TRPV4 MAP7 Co-immunoprecipitation HEK293 Mouse 785-808 Mouse Full-length 14517216
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPV4 MAP7 Cell surface biotinylation Increase in plasma membrane level 14517216
TRPV4 MAP7 Patch clamp Activation 14517216
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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