TRPV4 / Calmodulin

Interaction: TRPV4Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c / CalmodulinDetail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPV4 Calmodulin Inference Prediction 12724311
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPV4 Calmodulin Fusion protein-pull down assay Mouse Full-length HEK293 lysates Not specified Not specified In vitro translation 22492541
TRPV4 Calmodulin Fusion protein-pull down assay Human 718-871 E. coli Not used HEK293T lysates 21837266
TRPV4 Calmodulin Fusion protein-pull down assay Human C-terminus E. coli Not specified Full-length Not specified 12724311
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPV4 Calmodulin Fusion protein-pull down assay Rat ARD domain Not specified Not determined 20926660
TRPV4 Calmodulin Fusion protein-pull down assay Chicken 132-383 Not specified Not determined 19864432
TRPV4 Calmodulin Fusion protein-pull down assay Human 718-871 Human Not determined 21837266
TRPV4 Calmodulin Fusion protein-pull down assay Human 812-831 Not specified Not determined 12724311
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPV4 Calmodulin Patch clamp Activation 12724311
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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