TRPV1 / Src
Interaction:
TRPV1
/
Src
/
Src
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPV1 | SRC | Inference | Prediction | 15084474 | |||||
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Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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| Validation: In vivo validation
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| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPV1 | SRC | Co-immunoprecipitation | Rat dorsal root ganglion neuron | 15084474 | |||||
| TRPV1 | SRC | Co-immunoprecipitation | HEK293 | 16319926 | |||||
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|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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| Characterization
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| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
| TRP channel | Interactor | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPV1 | SRC | Fusion protein-pull down assay | Human | 1-433 | Rat | 83-144 | 16319926 | ||
| TRPV1 | SRC | Fusion protein-pull down assay | Human | 681-839 | Rat | 83-144 | 16319926 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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| Functional consequence
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| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
| TRPV1 | SRC | Calcium measurement | Activation | 16319926 | |||||||
| TRPV1 | SRC | In vitro PTM assay | Phosphorylayion (Tyr-200) | 16319926 | |||||||
| TRPV1 | SRC | In vivo PTM assay | Phosphorylation | 15084474 | |||||||
| TRPV1 | SRC | In vivo PTM assay | Phosphorylayion (Tyr-200) | 16319926 | |||||||
| TRPV1 | SRC | Patch clamp | Activation | 15084474 | |||||||
| TRPV1 | SRC | Patch clamp | Activation | 16319926 | |||||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)