TRPV1 / PRKD1/PKCƬ
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Screening
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Experimental screening | Non-experimental screening | Reference | |||||||
TRP channel construct | Interactor source | ||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
TRPV1 | PRKD1/PKCƬ | Inference | Prediction | 15471852 |
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | ||||||||
TRP channel construct | Interactor construct | ||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | |
TRPV1 | PRKD1/PKCƬ | Fusion protein-pull down assay | Rat | Full-length | E. coli | Not specified | Full-length | Not specified | 15471852 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | |||
TRPV1 | PRKD1/PKCƬ | Co-immunofluorescence staining | Rat dorsal root ganglion section | 18063480 | |||||
TRPV1 | PRKD1/PKCƬ | Co-immunoprecipitation | Rat dorsal root ganglion lysates | 18063480 | |||||
TRPV1 | PRKD1/PKCƬ | Co-immunoprecipitation | CHO | Rat | Full-length | Human | Full-length | 15471852 | |
TRPV1 | PRKD1/PKCƬ | Co-immunoprecipitation | Rat dorsal root ganglion neuron | 15471852 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
TRP channel | Interactor | ||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | |||
TRPV1 | PRKD1/PKCƬ | Fusion protein-pull down assay | Rat | 99-118 | Human | Not determined | 15471852 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
TRPV1 | PRKD1/PKCƬ | Calcium measurement | Activation | 15471852 | |||||||
TRPV1 | PRKD1/PKCƬ | In vitro PTM assay | Phosphorylation (Ser-116) | 15471852 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
