TRPV1 / PKCƢ
Interaction:
TRPV1
/
PKCƢ
/
PKCƢ
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPV1 | PKCƢ | Inference | Prediction | 24920628 | |||||
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Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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| Validation: In vivo validation
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| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPV1 | PKCƢ | Co-immunofluorescence staining | HEK293 | Human | Full-length | Human | Full-length | 24920628 | |
| TRPV1 | PKCƢ | Co-immunofluorescence staining | Rat dorsal root ganglion cell | 24920628 | |||||
| TRPV1 | PKCƢ | Co-immunoprecipitation | Rat dorsal root ganglion cell | 24920628 | |||||
| TRPV1 | PKCƢ | Co-immunoprecipitation | HEK293 | Human | Full-length | Human | Full-length | 24920628 | |
(:
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|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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| Characterization
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| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
| TRP channel | Interactor | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPV1 | PKCƢ | Fusion protein-pull down assay | Human | 1-433 | Human | 341-673 | 24920628 | ||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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|
| Functional consequence
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| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
| TRPV1 | PKCƢ | In vivo PTM assay | Phosphorylation (Thr-705) | 24920628 | |||||||
| TRPV1 | PKCƢ | Patch clamp | Activation | 24920628 | |||||||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)