TRPP2 / PKD1L3/Polycystin-1L3
Interaction:
TRPP2
/
PKD1L3/Polycystin-1L3
/
PKD1L3/Polycystin-1L3
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPP2 | PKD1L3/Polycystin-1L3 | Inference | Prediction | 16891422 | |||||
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPP2 | PKD1L3/Polycystin-1L3 | Co-immunofluorescence staining | Mouse taste cell | 16891422 | |||||
| TRPP2 | PKD1L3/Polycystin-1L3 | Co-immunoprecipitation | HEK293T | Mouse | Full-length | Mouse | Full-length | 16891422 | |
| TRPP2 | PKD1L3/Polycystin-1L3 | Co-immunoprecipitation | HEK293T | Mouse | Full-length | Mouse | Full-length | 20538909 | |
| TRPP2 | PKD1L3/Polycystin-1L3 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 23212381 | |
| TRPP2 | PKD1L3/Polycystin-1L3 | Co-immunoprecipitation | HEK293T | Mouse | Full-length | Mouse | Full-length | 18535624 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Characterization
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
| TRP channel | Interactor | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPP2 | PKD1L3/Polycystin-1L3 | Co-immunoprecipitation | Mouse | Full-length | Mouse | 1594-2151 | 16891422 | ||
| TRPP2 | PKD1L3/Polycystin-1L3 | Co-immunoprecipitation | Mouse | Not determined | Mouse | 1896-2040 | 20538909 | ||
| TRPP2 | PKD1L3/Polycystin-1L3 | Single-molecule photobleaching | 3:1 | 23212381 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Functional consequence
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
| TRPP2 | PKD1L3/Polycystin-1L3 | Co-immunofluorescence staining | Increase in plasma membrane level | 20538909 | |||||||
| TRPP2 | PKD1L3/Polycystin-1L3 | Patch clamp | New channel creation | 23212381 | |||||||
| TRPP2 | PKD1L3/Polycystin-1L3 | Patch clamp | New channel creation | 18535624 | |||||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)