TRPP1 / TRPC1

Interaction: TRPP1Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c / TRPC1Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 TRPC1 Inference Prediction 10097141
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPP1 TRPC1 Fusion protein-pull down assay Human 680-968 In vitro translation Human 662-750 E. coli 10097141
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPP1 TRPC1 Co-immunofluorescence staining HEK293 tsA 201 Human Full-length Human Full-length 19850920
TRPP1 TRPC1 Co-immunofluorescence staining mIMCD-3 18323855
TRPP1 TRPC1 Co-immunofluorescence staining HEK293T Human Full-length Human Full-length 10097141
TRPP1 TRPC1 Co-immunoprecipitation HEK293T Not specified Not specified Human Full-length 14530267
TRPP1 TRPC1 Co-immunoprecipitation Human glomerular mesangial cell Not used Human Full-length 18256307
TRPP1 TRPC1 Co-immunoprecipitation HEK293 Human Full-length Mouse Full-length 19812035
TRPP1 TRPC1 Co-immunoprecipitation HEK293 tsA 201 Human Full-length Human Full-length 19850920
TRPP1 TRPC1 Co-immunoprecipitation Rat kidney tissue 18323855
TRPP1 TRPC1 Co-immunoprecipitation HEK293 tsA 201 Human Full-length Human Full-length 20682256
TRPP1 TRPC1 Co-immunoprecipitation Rat mesenteric artery endothelial cell Human Full-length Human Full-length 25114176
TRPP1 TRPC1 Co-immunoprecipitation HEK293 Human Full-length Human Full-length 25114176
TRPP1 TRPC1 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 10097141
TRPP1 TRPC1 Fluorescence resonance energy transfer HEK293 Human Full-length Human Full-length 25114176
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPP1 TRPC1 Atomic force microscopy(AFM) analysis 2:2 19850920
TRPP1 TRPC1 Atomic force microscopy(AFM) analysis 2:2 19193631
TRPP1 TRPC1 Co-immunoprecipitation Human 1-643 Human Not determined 10097141
TRPP1 TRPC1 Co-immunoprecipitation Human 679-968 Human Not determined 10097141
TRPP1 TRPC1 Yeast two-hybrid Human 822-895 Human 639-750 10097141
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPP1 TRPC1 Patch clamp New channel creation 18323855
TRPP1 TRPC1 Patch clamp New channel creation 25114176
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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