TRPM8 / Gơq

Interaction: TRPM8Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c / GơqDetail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPM8 Gơq Inference Prediction 22460725
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPM8 Gơq Fusion protein-pull down assay Human Full-length HEK293 lysates Human Full-length HEK293 lysates 22750945
TRPM8 Gơq Fusion protein-pull down assay Human Full-length E. coli Human Full-length HEK293 lysates 22750945
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPM8 Gơq Co-immunofluorescence staining HEK293 Not specified Full-length Not specified Full-length 22460725
TRPM8 Gơq Co-immunoprecipitation Mouse dorsal root ganglion cell 22750945
TRPM8 Gơq Co-immunoprecipitation HEK293 Rat Full-length Not used 23508958
TRPM8 Gơq Fluorescence resonance energy transfer HEK293 Not specified Full-length Not specified Full-length 22460725
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPM8 Gơq Fusion protein-pull down assay Human 1-691 Human Not determined 22750945
TRPM8 Gơq Fusion protein-pull down assay Human 980-1104 Human Not determined 22750945
TRPM8 Gơq Fusion protein-pull down assay Human Not determined Human 222-245 22750945
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPM8 Gơq Patch clamp Inhibition 22750945
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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