TRPM7 / PLCƢ2
Interaction:
TRPM7
/
PLCƢ2
/
PLCƢ2
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPM7 | PLCƣ2 | Inference | Prediction | 22759789 | |||||
| TRPM7 | PLCƢ2 | Inference | Prediction | 11941371 | |||||
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:
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:
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|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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|
| Validation: In vitro validation
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|---|---|---|---|---|---|---|---|---|---|
| Assay with recombinant proteins | Reference | ||||||||
| TRP channel construct | Interactor construct | ||||||||
| TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | |
| TRPM7 | PLCƢ2 | Fusion protein-pull down assay | Rat | 1352-1862 | E. coli | Rat | Full-length | HEK293T lysates | 11941371 |
| TRPM7 | PLCƢ2 | Fusion protein-pull down assay | Not specified | Kinase domain | E. coli | Not specified | Full-length | HEK293 lysates | 22180838 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPM7 | PLCƣ2 | Co-immunoprecipitation | DT40 | Mouse | Full-length | Not used | 22759789 | ||
| TRPM7 | PLCƢ2 | Co-immunoprecipitation | HEK293T | Rat | Full-length | Rat | Full-length | 11941371 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Functional consequence
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|---|---|---|---|---|---|---|---|---|---|---|---|
| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
| TRPM7 | PLCƢ2 | Patch clamp | Inhibition | 11941371 | |||||||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)