TRPM6 / TRPM7
Interaction:
TRPM6
/
TRPM7
/
TRPM7
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPM6 | TRPM7 | Inference | Prediction | 14976260 | |||||
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:
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Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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| Validation: In vivo validation
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| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPM6 | TRPM7 | Fluorescence resonance energy transfer | HEK293 | Human | Full-length | Mouse | Full-length | 14976260 | |
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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| Characterization
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| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
| TRP channel | Interactor | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPM6 | TRPM7 | Fusion protein-pull down assay | Mouse | 1711-2028 | Mouse | 1548-1863 | 19228120 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Functional consequence
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| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
| TRPM6 | TRPM7 | Patch clamp | Activation | 14976260 | |||||||
| TRPM6 | TRPM7 | Patch clamp | New channel creation | 24385424 | |||||||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)