TRPC6 / PKA
Interaction:
TRPC6
/
PKA
/
PKA
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPC6 | PKA | Inference | Prediction | 21799177 | |||||
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Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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| Validation: In vivo validation
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| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPC6 | PKA | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Not used | 21799177 | ||
| TRPC6 | PKA | Co-immunoprecipitation | HEK293T | Human | Full-length | Not specified | Not specified | 23645677 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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| Functional consequence
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| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
| TRPC6 | PKA | In vitro PTM assay | Phosphorylation (Thr-69) | 22001259 | |||||||
| TRPC6 | PKA | In vitro PTM assay | Phosphorylation (Ser-28) | 22001259 | |||||||
| TRPC6 | PKA | In vitro PTM assay | Phosphorylation (Thr-70) | 23645677 | |||||||
| TRPC6 | PKA | In vivo PTM assay | Phosphorylation (Thr-70) | 23645677 | |||||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)