TRPC6 / FYN
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Screening
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Experimental screening | Non-experimental screening | Reference | |||||||
TRP channel construct | Interactor source | ||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
TRPC6 | FYN | Inference | Prediction | 14761972 |
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | ||||||||
TRP channel construct | Interactor construct | ||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | |
TRPC6 | FYN | Fusion protein-pull down assay | Mouse | Full-length | HEK293 lysates | Human | 149-257 | E. coli | 14761972 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | |||
TRPC6 | FYN | Co-immunofluorescence staining | CHO-K1 | Mouse | Full-length | Human | Full-length | 14761972 | |
TRPC6 | FYN | Co-immunoprecipitation | Rat brain microsome | 14761972 | |||||
TRPC6 | FYN | Co-immunoprecipitation | COS-7 | Mouse | Full-length | Human | Full-length | 14761972 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
TRP channel | Interactor | ||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | |||
TRPC6 | FYN | Fusion protein-pull down assay | Mouse | 1-388 | Human | 149-257 | 14761972 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
TRPC6 | FYN | In vivo PTM assay | Phosphorylation | 14761972 | |||||||
TRPC6 | FYN | Patch clamp | Activation | 14761972 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
