TRPC3 / IP3R3

Interaction: TRPC3Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c / IP3R3Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC3 IP3R3 Inference Prediction 10611319
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPC3 IP3R3 Fusion protein-pull down assay Human 676-848 In vitro translation Human 638-926 E. coli 10611319
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC3 IP3R3 Co-immunofluorescence staining HEK293 Human Full-length Not used 11524429
TRPC3 IP3R3 Co-immunofluorescence staining Mouse pancreatic acini 16887806
TRPC3 IP3R3 Co-immunofluorescence staining Mouse parotid acini 16887806
TRPC3 IP3R3 Co-immunofluorescence staining Mouse submandibular gland duct 16887806
TRPC3 IP3R3 Co-immunoprecipitation HEK293 Human Full-length Not used 14505576
TRPC3 IP3R3 Co-immunoprecipitation HEK293 Human Full-length Not used 11524429
TRPC3 IP3R3 Co-immunoprecipitation Mouse brain tissue 16887806
TRPC3 IP3R3 Co-immunoprecipitation Mouse pancreatic tissue 16887806
TRPC3 IP3R3 Co-immunoprecipitation Mouse submandibular gland lysates 16887806
TRPC3 IP3R3 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 10611319
TRPC3 IP3R3 Co-immunoprecipitation MDCK Not specified Full-length Not used 15623527
TRPC3 IP3R3 Co-immunoprecipitation HEK293 Human Full-length Not used 10983988
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPC3 IP3R3 Co-immunoprecipitation Human 775-787 Rat Not determined 18276585
TRPC3 IP3R3 Fusion protein-pull down assay Human 777-797 Human 669-698 10611319
TRPC3 IP3R3 Fusion protein-pull down assay Human 777-797 Human 751-821 10611319
TRPC3 IP3R3 Fusion protein-pull down assay Human 761-795 Human 669-698 11248050
TRPC3 IP3R3 Fusion protein-pull down assay Human 761-795 Human 669-698 11290752
TRPC3 IP3R3 Fusion protein-pull down assay Mouse 725-848 Human 681-698 11290752
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPC3 IP3R3 Calcium measurement Activation 10611319
TRPC3 IP3R3 Calcium measurement Inhibition 10611319
TRPC3 IP3R3 Patch clamp Activation 11248050
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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