TRPC3 / IP3R1

Interaction: TRPC3Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c / IP3R1Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC3 IP3R1 Affinity purification-mass spectrometry Not used as a bait Rat Brain Crude membranes 18205297
TRPC3 IP3R1 Inference Prediction 10518223
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC3 IP3R1 Co-immunoprecipitation HEK293 Human Full-length Not used 11524429
TRPC3 IP3R1 Co-immunoprecipitation Rat cerebral arterial lysates 20378853
TRPC3 IP3R1 Co-immunoprecipitation Rat mesenteric artery lysates 23045459
TRPC3 IP3R1 Co-immunoprecipitation Rat brain lysates 18205297
TRPC3 IP3R1 Co-immunoprecipitation HEK293 Human Full-length Rat Full-length 10518223
TRPC3 IP3R1 Co-immunoprecipitation MDCK Not specified Full-length Not used 15623527
TRPC3 IP3R1 Co-immunoprecipitation HEK293 20022948
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPC3 IP3R1 Co-immunoprecipitation Human Not determined Rat IP3 binding domain 10518223
TRPC3 IP3R1 Fusion protein-pull down assay Mouse 725-848 Not specified 654-688 11290752
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPC3 IP3R1 Calcium measurement Activation 10518223
TRPC3 IP3R1 Patch clamp Activation 10518223
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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