TRPC1 / TRPV4

Interaction: TRPC1Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c / TRPV4Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC1 TRPV4 Inference Prediction 20705915
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPC1 TRPV4 Co-immunofluorescence staining HEK293 Human Full-length Mouse Full-length 20093626
TRPC1 TRPV4 Co-immunofluorescence staining Rat mesenteric artery endothelial cell lysates 20093626
TRPC1 TRPV4 Co-immunoprecipitation HEK293 Human Full-length Mouse Full-length 20093626
TRPC1 TRPV4 Co-immunoprecipitation Rat mesenteric artery endothelial cell lysates 20093626
TRPC1 TRPV4 Co-immunoprecipitation Rat mesenteric artery endothelial cell Human Full-length Mouse Full-length 25114176
TRPC1 TRPV4 Co-immunoprecipitation HEK293 Human Full-length Mouse Full-length 25114176
TRPC1 TRPV4 Co-immunoprecipitation Porcine coronary artery 25139746
TRPC1 TRPV4 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 20093626
TRPC1 TRPV4 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 20705915
TRPC1 TRPV4 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 21871867
TRPC1 TRPV4 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 25114176
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPC1 TRPV4 Fluorescence resonance energy transfer 2:2 21871867
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPC1 TRPV4 Cell surface biotinylation Increase in plasma membrane level 20705915
TRPC1 TRPV4 Co-immunofluorescence staining Increase in plasma membrane level 20705915
TRPC1 TRPV4 Patch clamp New channel creation 25114176
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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