TRPC1 / I-MFA
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Screening
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Experimental screening | Non-experimental screening | Reference | |||||||
TRP channel construct | Interactor source | ||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
TRPC1 | I-MFA | Yeast two-hybrid | Human | 639-750 | Mouse | Embryonic | cDNA library | 14530267 | |
TRPC1 | I-MFA | Yeast two-hybrid | Human | 639-750 | Human | Fetal kidney | cDNA library | 14530267 |
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | ||||||||
TRP channel construct | Interactor construct | ||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | |
TRPC1 | I-MFA | Fusion protein-pull down assay | Human | 639-750 | E. coli | Human | Full-length | E. coli | 14530267 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | |||
TRPC1 | I-MFA | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 14530267 | |
TRPC1 | I-MFA | Co-immunoprecipitation | Rat liver tissue | 14530267 | |||||
TRPC1 | I-MFA | Co-immunoprecipitation | NALM-6 | 14530267 | |||||
TRPC1 | I-MFA | Co-immunoprecipitation | Rat kidney tissue | 14530267 | |||||
TRPC1 | I-MFA | Co-immunoprecipitation | HEK293T | Mouse | Full-length | Mouse | Full-length | 23770672 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
TRPC1 | I-MFA | Patch clamp | Inhibition | 14530267 | |||||||
TRPC1 | I-MFA | Patch clamp | Desensitization | 23770672 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
