TRPC1 / Homer-3
Interaction:
TRPC1
/
Homer-3
/
Homer-3
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPC1 | Homer-3 | Inference | Prediction | 14505576 | |||||
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:
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:
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|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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| Validation: In vitro validation
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| Assay with recombinant proteins | Reference | ||||||||
| TRP channel construct | Interactor construct | ||||||||
| TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | |
| TRPC1 | Homer-3 | Fusion protein-pull down assay | Not used | Rat cerebellum lysates | Not specified | Full-length | E. coli | 14505576 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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|
| Validation: In vivo validation
|
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| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPC1 | Homer-3 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 14505576 | ||
| TRPC1 | Homer-3 | Co-immunoprecipitation | Rat cerebellum lysates | 14505576 | |||||
| TRPC1 | Homer-3 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 19945390 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Characterization
|
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|---|---|---|---|---|---|---|---|---|---|
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
| TRP channel | Interactor | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPC1 | Homer-3 | Co-immunoprecipitation | Human | 645-648 | Human | EVH1 domain | 14505576 | ||
| TRPC1 | Homer-3 | Fusion protein-pull down assay | Human | 20-23 | Not specified | EVH1 domain | 14505576 | ||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)