TRPC1 / Calmodulin

Interaction: TRPC1Detail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c / CalmodulinDetail bc8838fa5bd2464c5553a5a10de82d112f40db7d921ce377f414735e0504230c
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPC1 Calmodulin Inference Prediction 11983166
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPC1 Calmodulin Fusion protein-pull down assay Human 649-793 E. coli Not specified Full-length Not specified 11983166
TRPC1 Calmodulin Fusion protein-pull down assay Human 1-341 In vitro translation Not specified Full-length E. coli 12601176
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPC1 Calmodulin Fluorescence probe labeling Human 720-749 Not specified Not determined 30 nM 11290752
TRPC1 Calmodulin Fusion protein-pull down assay Human 719-751 Not specified Not determined 11983166
TRPC1 Calmodulin Fusion protein-pull down assay Human 758-793 Not specified Not determined 11983166
TRPC1 Calmodulin Fusion protein-pull down assay Human 719-751 Not specified Not determined 11290752
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPC1 Calmodulin Calcium measurement Inhibition 11983166
TRPC1 Calmodulin Patch clamp Inhibition 11983166
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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