TRPC1 / Calmodulin
Interaction:
TRPC1
/
Calmodulin
/
Calmodulin
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPC1 | Calmodulin | Inference | Prediction | 11983166 | |||||
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Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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| Validation: In vitro validation
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| Assay with recombinant proteins | Reference | ||||||||
| TRP channel construct | Interactor construct | ||||||||
| TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | |
| TRPC1 | Calmodulin | Fusion protein-pull down assay | Human | 649-793 | E. coli | Not specified | Full-length | Not specified | 11983166 |
| TRPC1 | Calmodulin | Fusion protein-pull down assay | Human | 1-341 | In vitro translation | Not specified | Full-length | E. coli | 12601176 |
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Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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| Characterization
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| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
| TRP channel | Interactor | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPC1 | Calmodulin | Fluorescence probe labeling | Human | 720-749 | Not specified | Not determined | 30 nM | 11290752 | |
| TRPC1 | Calmodulin | Fusion protein-pull down assay | Human | 719-751 | Not specified | Not determined | 11983166 | ||
| TRPC1 | Calmodulin | Fusion protein-pull down assay | Human | 758-793 | Not specified | Not determined | 11983166 | ||
| TRPC1 | Calmodulin | Fusion protein-pull down assay | Human | 719-751 | Not specified | Not determined | 11290752 | ||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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|
| Functional consequence
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| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | |||||
| TRPC1 | Calmodulin | Calcium measurement | Inhibition | 11983166 | |||||||
| TRPC1 | Calmodulin | Patch clamp | Inhibition | 11983166 | |||||||
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