TRPC1 / ơ1-syntrophin
Interaction:
TRPC1
/
ơ1-syntrophin
/
ơ1-syntrophin
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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Screening
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| Experimental screening | Non-experimental screening | Reference | |||||||
| TRP channel construct | Interactor source | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | ||
| TRPC1 | ơ1-syntrophin | Inference | Prediction | 17202249 | |||||
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Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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|
| Validation: In vitro validation
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| Assay with recombinant proteins | Reference | ||||||||
| TRP channel construct | Interactor construct | ||||||||
| TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | |
| TRPC1 | ơ1-syntrophin | Fusion protein-pull down assay | Not used | C57BL/10 mouse muscle cell lysates | Mouse | 75-170 | E. coli | 19812031 | |
| TRPC1 | ơ1-syntrophin | Fusion protein-pull down assay | Not used | Mouse myotube lysates | Not specified | 75-170 | E. coli | 17202249 | |
(:
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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|
| Validation: In vivo validation
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| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | |||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | ||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPC1 | ơ1-syntrophin | Co-immunoprecipitation | SolD6 | 19812031 | |||||
| TRPC1 | ơ1-syntrophin | Co-immunoprecipitation | C57BL/10 mouse muscle cell | 19812031 | |||||
| TRPC1 | ơ1-syntrophin | Co-immunoprecipitation | Mouse muscle lysates | 17202249 | |||||
| TRPC1 | ơ1-syntrophin | Co-immunoprecipitation | SolC1 | Not used | Mouse | Full-length | 17202249 | ||
| TRPC1 | ơ1-syntrophin | Co-immunoprecipitation | SolD6 | Not used | Mouse | Full-length | 17202249 | ||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
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|
| Characterization
|
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|---|---|---|---|---|---|---|---|---|---|
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | ||||||
| TRP channel | Interactor | ||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | |||
| TRPC1 | ơ1-syntrophin | Fusion protein-pull down assay | Mouse | Not determined | Mouse | 75-170 | 19812031 | ||
| TRPC1 | ơ1-syntrophin | Fusion protein-pull down assay | Mouse | Not determined | Not specified | 75-170 | 17202249 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)